Relation to proteome Transcriptome

the transcriptome can seen precursor proteome, is, entire set of proteins expressed genome.

however, analysis of relative mrna expression levels can complicated fact relatively small changes in mrna expression can produce large changes in total amount of corresponding protein present in cell. 1 analysis method, known gene set enrichment analysis, identifies coregulated gene networks rather individual genes up- or down-regulated in different cell populations.

although microarray studies can reveal relative amounts of different mrnas in cell, levels of mrna not directly proportional expression level of proteins code for. number of protein molecules synthesized using given mrna molecule template highly dependent on translation-initiation features of mrna sequence; in particular, ability of translation initiation sequence key determinant in recruiting of ribosomes protein translation. complete protein complement of cell or organism known proteome.