Gemin6 and Gemin7 LSm
the smn complex (described under biogenesis of snrnps ) composed of smn protein , gemin2-8. 2 of these, gemin 6 , gemin7 have been discovered have lsm structure, , form heterodimer. these may have chaperone function in smn complex assist formation of sm ring on sm-class snrnas. prmt5 complex composed of prmt5, picln, wd45 (mep50). picln helps form sm opened ring on smn complex. smn complex assists in assembly of snrnps sm ring in open conformation on smn complex , sm ring loaded onto snrna smn complex.
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