COF synthesis Two-dimensional polymer

boronate ester equilibria used prepare various 2d cofs

it possible synthesize cofs using both dynamic covalent , non-covalent chemistry. kinetic approach involves stepwise process of polymerizing pre-assembled 2d-monomer while thermodynamic control exploits reversible covalent chemistry allow simultaneous monomer assembly , polymerization. under thermodynamic control, bond formation , crystallization occur simultaneously. covalent organic frameworks formed dynamic covalent bond formation involves chemical reactions carried out reversibly under conditions of equilibrium control. because formation of cofs in dynamic covalent formation occurs under thermodynamic control, product distributions depend on relative stabilities of final products. covalent assembly form 2d cofs has been done using boronate esters catechol acetonides in presence of lewis acid (bf3*oet2).

2d polymerization under kinetic control relies on non-covalent interactions , monomer assembly prior bond formation. monomers can held in pre-organized position non-covalent interactions, such hydrogen bonding or van der waals.